Pathologist found blood clots in almost every organ during autopsies on Covid-19 patients – CNN

Dr. Amy Rapkiewicz, the chairman of the department of pathology at NYU Langone Medical Center, spoke to Erin Burnett on OutFront Thursday night.

Some patients are known to develop blood clotting issues, but the degree and the extent to which that occurs was described as “dramatic” by Rapkiewicz.

In the early stages of the pandemic, bedside clinicians noticed a lot of blood clotting “in lines and various large vessels,” she said.

“What we saw at autopsy was sort of an extension of that,” she said. “The clotting was not only in the large vessels but also in the smaller vessels.

“And this was dramatic, because though we might have expected it in the lungs, we found it in almost every organ that we looked at in our autopsy study,” she said. Rapkiewicz’s study outlining her findings was published at the end of June in The Lancet journal EClinicalMedicine.

The autopsies also showed something unusual about megakaryocytes, or large bone marrow cells. They usually don’t circulate outside the bones and lungs, Rapkiewicz said.

“We found them in the heart and the kidneys and the liver and other organs,” she said. “Notably in the heart, megakaryocytes produce something called platelets that are intimately involved in blood clotting.”
Researchers hope to discover how these cells influence small vessel clotting in, she said.

Pathologists have been surprised by something they didn’t find.

During early stages of the pandemic, doctors thought the virus would provoke inflammation in the heart with myocarditis, she said.

But autopsies have found a very low incidents of myocarditis, Rapkiewicz said.

She said that one of the “opportunities — if there is one to count in the virus” is that pathologists have had a chance to examine the organs of many victims and investigate the disease processes that take place. She said that opportunity really wasn’t available with H1N1 or the original SARS outbreak.


Unknown pneumonia said to be deadlier than coronavirus is sweeping across Kazakhstan – Daily Mail

‘Unknown pneumonia’ said to be deadlier than coronavirus is sweeping across Kazakhstan, Chinese embassy says

  • More than 32,000 cases of the ‘unknown pneumonia’ have been reported in Kazakhstan from June 29 to July 5, along with 451 deaths
  • The Chinese embassy says Kazakhstan saw 1,772 pneumonia deaths in the first half of the year, including 628 in June, some of whom were Chinese nationals
  • It’s unknown why the embassy refers to the pneumonia as ‘unknown’ or what information it has about the outbreak
  • Chinese citizens in the country have been warned to take precautions similar to COVID-19 such as social distancing and wearing face masks 
  • Meanwhile, there are 53,021 coronavirus cases  in Kazakhstan and 264 deaths 

A fatal ‘unknown pneumonia’ with a death rate far higher than that of COVID-19 has reportedly broken out in Kazakhstan, Chinese officials have warned.

According to the Chinese embassy’s website, which is citing local media reports, the Atyrau and Aktobe provinces, as well as the city of Skymkent, have seen spikes in cases of the disease since mid-June.

Kazakhstan’s Ministry says it has recorded more than 32,000 cases of pneumonia between June 29 and July 5 alone, along with 451 deaths.

The embassy states that Kazakhstan saw 1,772 pneumonia deaths in the first half of the year, including 628 in June, some of whom were Chinese nationals.

The warning is oddly reminiscent of when Chinese scientists announced to the world in January that they had discovered  a never-before-seen strain of coronavirus that resembled pneumonia, now known as SARS-CoV-2.

More than 32,000 cases of the 'unknown pneumonia' have been reported in Kazakhstan from June 29 to July 5 along with 451 deaths compared to 53,021 coronavirus cases and 264 deaths. Pictured: A healthcare worker gives a test to a medical staffer near Halyk Arena in Almaty, Kazakhstan, July 5

More than 32,000 cases of the 'unknown pneumonia' have been reported in Kazakhstan from June 29 to July 5 along with 451 deaths compared to 53,021 coronavirus cases and 264 deaths. Pictured: A healthcare worker gives a test to a medical staffer near Halyk Arena in Almaty, Kazakhstan, July 5

More than 32,000 cases of the ‘unknown pneumonia’ have been reported in Kazakhstan from June 29 to July 5 along with 451 deaths compared to 53,021 coronavirus cases and 264 deaths. Pictured: A healthcare worker gives a test to a medical staffer near Halyk Arena in Almaty, Kazakhstan, July 5

The embassy has described the illness as an ‘unknown pneumonia’ despite officials in Kazakhstan saying it is merely a pneumonia epidemic.

It’s currently unclear why the Chinese embassy has described the pneumonia as ‘unknown’ or any information it has about the outbreak.  

‘The death rate of this disease is much higher than the novel coronavirus,’ the embassy wrote in a warning to Chinese citizens in Kazakhstan. 

‘The country’s health departments are conducting comparative research into the pneumonia virus, but have yet to identify the virus.’     

Diplomats urged Chinese nationals to take the same precautions as they were with coronavirus, which originated in Wuhan and has infected more than 12  million people around the globe.  

This includes people not leaving their homes unless necessary, wearing a face mask, practicing social distancing and washing hands thoroughly and often.

‘Some 300 people diagnosed with pneumonia are being hospitalized every day,’ Saule Kisikova, the health care department chief in Kazakh capital Nur-Sultan, told state news agency Kazinform.

Chief sanitary officer Ayzhan Esmagambetova says the mortality rate from pneumonia has increased in Kazakhstan four times in June 2020 compared to the same time frame last year. 

She added that many of those who have fallen ill were not diagnosed with COVID-19, reported RT News

Meanwhile, there are 53,021 death from coronavirus in Kazakhstan and 264 deaths, according to Johns Hopkins University’s COVID-19 Dashboard.

The country went into a strict lockdown on March 16, but later lifted many of the restrictions on May 11.

On Sunday, Kazakhstan’s President Kassym-Jomart Tokayev imposed a second round of restrictions after a surge in coronavirus cases.

On Thursday, Kazakhstani officials recorded 1,962 new COVID-19 cases, the highest-single day increase, Kazinform reported.

Tokayev said the nation was ‘in fact facing the second coronavirus wave coupled with a huge uptick in pneumonia cases,’ according to Russian news agency Tass.   


3 deaths since Monday from Canyon Creek Memory Care COVID-19 outbreak in Billings – Billings Gazette

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LIVE: COVID-19 update for San Antonio area – WOAI

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Researchers know what people the coronavirus is more likely to kill – BGR

  • A massive coronavirus Oxford study provides the same tips as previous work on the matter when it comes to the risk factors that can lead to COVID-19 complications and death.
  • The study looked at records belonging to 17 million Britons, including more than ten thousand COVID-19 fatalities, and identified the same risk factors are previous work.
  • Existing medical conditions, age, sex, and race are all factors that can increase the risk of death of coronavirus patients.

The novel coronavirus pandemic is here to stay for a much longer while than we may have hoped. It’s not that we expected the virus to be eradicated anytime soon. That may never happen, and we’ll have to learn to live with COVID-19. But the world’s coronavirus curve is far from being flattened. In fact, the virus needed just five days to infect its twelfth million people, which is another record that COVID-19 broke. We can’t even be sure whether we’re nearing the peak of the pandemic globally. Some nations have quashed their outbreaks and are now fighting to contain smaller ones. But countries like America, Brazil, and India continue to report tens of thousands of daily cases.

As we’ve already explained, the world is much better positioned to deal with COVID-19 patients than in March. Therapies work, and severe cases aren’t necessarily doomed to death. But the fatality rate remains high as there’s no cure available that can prevent the disease or treat the massive complications. It’s up to individuals to protect themselves as much as possible, by social distancing whenever they can, wearing face masks, and washing hands often. The virus can infect anyone regardless of age, social status, or access to high-quality medical care. And it can kill anyone, regardless of comorbidities. That’s what makes it so dangerous. But researchers know exactly what kind of people SARS-CoV-2 is more likely to kill, and it’s those people who should take all the precautions available to them to prevent infection.

Published in Nature, the study doesn’t deliver any surprising conclusions. It’s the same types of existing medical conditions, combined with age, sex, and race that make COVID-19 more dangerous for more people. But the Oxford study is the world’s biggest such research.

The researchers looked at health data for 17 million people in England, which makes it the largest of its kind. The researchers looked at de-identified health records belonging to 40% of England’s population. That’s 17,278,392 adults tracked over three months. Of them, 10,926 died of COVID-19 and COVID-19 complications.

“A lot of previous work has focused on patients that present at hospital,” Oxford’s Dr. Ben Goldacre told MSN. “That’s useful and important, but we wanted to get a clear sense of the risks as an everyday person. Our starting pool is literally everybody.”

The researchers found that patients older than 80 were at least 20 times more likely to die from COVID-19 than those in their 50s. Or hundreds of times more likely to die than people under 40. That’s a “jaw-dropping” difference, Goldacre said.

Men were more likely to die than women of the same age. Other conditions, including obesity, diabetes, severe asthma, and compromised immunity, were also linked to poor outcomes. Socioeconomic factors like poverty also increase a person’s chance of dying of COVID-19.

The study also looked at the effects of race and ethnicity on COVID-19-related deaths. Roughly 11% of patients were identified as nonwhite, and the researchers found that black and South Asian people were at higher risk of dying than white patients. Even after the scientists made corrections to account for age, sex, and medical conditions, the trend persisted.

The researchers also removed variables like chronic heart disease to focus solely on the effects of race and ethnicity. The heart condition is a risk factor for COVID-19, but it’s also more prevalent among black people. But black people are also more likely to experience stress and be denied medical service, so the disparity in heart disease may itself be influenced by racism. Some criticized this approach, as ignoring the heart disease risk could lead to wrong conclusions about the relationship between race and ethnicity and COVID-19 deaths.

Despite some criticism about methodology, the study still reaffirms the same concerns about at-risk patients observed from the early days of the pandemic. The scope of the study further serves to verify earlier conclusions. At the same time, we did see extensive studies that had to be retracted after it became clear that the dataset could not be audited by independent reviewers. That’s not to say the Oxford study is in the same boat. But any COVID-19 research can definitely benefit from additional confirmations.

Johns Hopkins University epidemiologist Avonne Connor said of the study that the large data set “is astounding,” saying that it adds “another layer to depicting who is at risk,” even though the conclusions are in line with what has been observed so far.

Assessing the risk factors correctly for COVID-19 cases could help authorities come up with better public health policies for preventing infection and providing proper access to potential cures and vaccines once they’re available.

Chris Smith started writing about gadgets as a hobby, and before he knew it he was sharing his views on tech stuff with readers around the world. Whenever he’s not writing about gadgets he miserably fails to stay away from them, although he desperately tries. But that’s not necessarily a bad thing.


Help wanted! Clinical trials launched to test COVID-19 vaccines – WCVB Boston

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What we know about coronavirus risks to school age children – CNN

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A new study shows who is most at risk of dying if they have the coronavirus: Report – PennLive

A new study, the largest so far its authors say, confirms that race, age, ethnicity, and sex can raise a person’s chances of dying from COVID-19.

An analysis of more than 17 million people in England has pinpointed factors that can raise a person’s chances of dying from COVID-19, according to a story by The New York Times.

Data, that included health records from approximately 40 percent of England’s population, was collected by the United Kingdom’s National Service. Of 17,278,392 adults tracked over three months, 10,926 reportedly died of COVID-19 or COVID-19-related complications.

Dr. Ben Goldacre of the University of Oxford, one of the authors of the study, said, “We wanted to get a clear sense of the risks as an everyday person. Our starting pool is literally everybody.”

Published Wednesday in Nature (a journal publishing research in all fields of science and technology), the findings match reports from other countries that identify older people, men, racial and ethnic minorities, and those with underlying health conditions among the most vulnerable populations.

Dr. Goldacre’s team found that patients older than 80 were at least 20 times more likely to die than those in their 50s, and hundreds of times more likely to die than those below the age of 40. The scale of this relationship was “jaw-dropping,” Dr. Goldacre said.

Other findings:

  • Men stricken with the virus had a higher likelihood of dying than women of the same age.
  • Medical conditions such as obesity, diabetes, severe asthma and compromised immunity were also linked to poor outcomes (agreeing with declarations from the Centers for Disease Control and Prevention in the U.S.).
  • A person’s chances of dying also tended to track with socioeconomic factors like poverty.

The data roughly mirrors what has been observed around the world and is not necessarily surprising, said Avonne Connor, an epidemiologist at Johns Hopkins University.

Particularly compelling were the study’s findings on race and ethnicity, said Sharrelle Barber, an epidemiologist at Drexel University. Roughly 11 percent of the patients that were tracked identified as nonwhite, and these individuals were at a higher risk of dying than white patients, even when statistical adjustments were made to factor in age, sex and medical conditions.

Other reports have pointed to social and structural inequities that are overly burdening racial and ethnic minority groups around the world with the coronavirus’s worst effects. For example, certain medical conditions that can aggravate, such as chronic heart disease, are more prevalent among Black people than white people.

The researchers removed such variables to focus solely on the effects of race and ethnicity. But because Black individuals are more likely to experience stress and be denied access to medical care in many parts of the world, the disparity in rates of heart disease may be influenced by racism, said Usama Bilal, an epidemiologist at Drexel University.

Experts agree that the causes of disparities are linked to structural racism. In the United States, Latino and Black residents are three times as likely to become infected by coronavirus as white residents, and nearly twice as likely to die.

Experts explain that due to the fact that many of these individuals work as front-line employees, or are tasked with essential in-person jobs that prevent them from sheltering in place at home. Some live in multi-generational households that can compromise effective physical distancing. Others must cope with language barriers and implicit bias when they seek medical care.

Any study publishing data on an ongoing, fast-shifting pandemic will inevitably be imperfect, said Julia Raifman, an epidemiologist at Boston University. But the new paper helps address “a real paucity of data on race, and these disparities are not just happening in the United States,” she goes on to say.

With regard to the racial inequities in this pandemic, Dr. Barber said, “We can learn from this study and improve on it. It gives us clues into what might be happening.”

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New symptoms arise as more young adults contract COVID-19 – WKRN News 2

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I can recover at home: Cosmetic surgeons see rise in patients amid pandemic – BBC News

A person has cosmetic surgery in the USImage copyright
Getty Images

Image caption

A number of clinics around the world say they are seeing a rise in people getting surgery

A number of cosmetic surgery clinics around the world are reporting a rise in people getting treatment during the coronavirus outbreak as they can hide their treatment behind a mask or work from home.

Despite the virus shutting businesses across the globe, a number of plastic surgery clinics have remained open, adopting stricter measures such as tests and more frequent cleaning.

Clinics in the US, Japan, South Korea and Australia have all seen a rise in patients coming in for treatment including lip fillers, botox, face lifts and nose jobs.

“I decided to get procedures done during quarantine because it allowed me to heal at my own pace,” Aaron Hernandez, who had lip fillers and buccal (cheek) fat removal in Los Angeles, told the BBC.

“Getting my lips done is not something that all men tend to do, so some people might find it different. Therefore I preferred to stay home and recover fully and people not know what work I had done once I’m out.”

The last time he had the procedure done before quarantine, he said, he had to go out in public for work and his lips were “extremely swollen and bruised”.

Rod J Rohrich, a cosmetic surgeon based in Texas, said he was seeing a lot more patients. “Even more than I would say is normal. We could probably operate six days a week if we wanted to. It’s pretty amazing,” he told the BBC.

He said usually people would have to factor in recovery at home when considering surgery but now that many people are working from home, this doesn’t need to be considered.

“They can actually recover at home and also they can have a mask that they wear when they go outside after a rhinoplasty or facelift. People want to resume their normal lives and part of that is looking as good as they feel.”

It’s not just the US that is seeing a rise in patients during the outbreak.

South Korea, well-known for its cosmetic surgery, was one of the first countries to see cases of the virus. Instead of enforcing a nationwide lockdown, it had a social distancing plan with people encouraged to work from home.

Cosmetic clinics have seen a decline in foreign visitors however locals have been coming to clinics for treatments. A number of clinics chose to offer a discount to locals.

Image copyright
Getty Images

Image caption

Cosmetic surgery is incredibly popular in South Korea and locals have flocked to clinics

A 54-year-old middle school teacher who had eyelid surgery in February told Joongang Daily that “every plastic surgery clinic I visited was packed”.

BK Hospital in Seoul told the BBC that at the beginning of the pandemic, people were nervous but more locals had begun to come to the clinic.

“Patients started to feel safe and comfortable to have surgery, despite The number of patients is increasing continuously,” the spokesperson said.

“Despite coronavirus, the number is estimated to increase by half compared to the same season last year.”

Inquiries from foreign patients have also increased, the spokesperson said.

“The number of online enquiries has increased significantly since there has been an opportunity to have online consultations and get prepared in advance for a trip once travelling restrictions will be lifted.”

Image copyright

Image caption

People in Japan were told to stay at home during the outbreak

Japan has not had an official lockdown, however Prime Minister Shinzo Abe announced a state of emergency which lasted until 31 May. People were asked to stay at home.

Despite this, clinics also saw a rise in patients wishing to get treatment.

The surge prompted Japan’s Association of Aesthetic Medicine to warn that cosmetic treatments were “not essential for many people”. It asked people to stay away from surgeries to “prevent further spread of the virus”.

“As an outpatient plastic surgery clinic equipped to provide same-day procedures, we have definitely seen an influx of patients who desire to have treatments done during this period,” said Michelle Tajiri, clinic co-ordinator at Bliss Clinic in Fukuoka.

“The main reasons are that they are off work and downtime isn’t an issue, as well as the fact that everyone is wearing masks and thus any facial procedures can be easily disguised.”

For Mr Hernandez, surgery during the outbreak was perfect timing. “It definitely allowed me more time to heal. I was able to take medication I probably would not have been able to take if I was driving and I was able to ice my lips and face area more.”